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Sulofenur [( N -(5-indanesulfonyl)- N ′-(4-chlorophenyl)urea, LY18664], the prototypic member of this class ( Figure 2C ), was evaluated in clinical trials on a variety of patients with kidney (Mahjoubi et al., 1993), ovary (O’Brien et al., 1992), breast (Talbot et al., 1993), lung (Munshi et al., 1993), and stomach (Kamthan et al., 1992) cancers

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Because the objective was integrative rather than exhaustive, formal inclusion/exclusion criteria and bias assessment tools typical of systematic reviews were not applied, in accordance with the flexible framework appropriate for narrative reviews