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Also, in vivo, it showed statistically significant reduction in tumor size, CD31 value, and markedly more active than in vitro because of the longer half-life, stability and the more active metabolites with allylic hydroxylation at C-19 and/or C-20 methyl carbons

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Lu (Biochim Biophys Acta, 2013) comprehensively reviewed the regulation of GCL by the Nrf2/ARE transcriptional pathway, the cysteine supply bottleneck that typically limits synthesis rates, and the dysregulation observed in oxidative stress disease models