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Instead of promoting GSH-conjugation reactions, cysteine-containing GSTs (Cys-GSTs) are able to perform deglutathionylation reactions similarly to glutaredoxins but the targets are usually different since glutaredoxin substrates are mostly oxidized proteins and Cys-GST substrates are metabolites
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Metformin has demonstrated the ability to reduce lipid oxidation in women with polycystic ovary syndrome 19 , it was also reported to suppress oxidative stress in patients with coronary artery disease 20
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