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It was developed in the 1980s to explore sunless tanning and skin-protection effects.¹ As a melanocortin receptor agonist, Melanotan-II promotes skin pigmentation and has been studied for its influence on sexual function, energy balance, and UV protection.¹ ² ³ ⁴ ⁸ ⁹ MT-II Fast Facts Class: Melanocortin receptor agonist (α-MSH analog) Design: Cyclic heptapeptide (lactam bridge) engineered for potency/stability Primary targets: MC1R (pigmentation), central MC3R/MC4R (sexual function, energy balance).⁸ Most studied effects: Increased pigmentation
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