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Specifically, their report suggested that hormonal changes associated with menopause can trigger a “bioenergetic crisis” in the female brain, creating a window of opportunity for early signs of AD pathology to emerge, as examined by brain imaging (MRI and PET scans) looking at the presence of increased amyloid-beta deposition and altered glucose metabolism during the menopausal transition (starting in midlife) [173]

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When the liver accumulates fat, it becomes vulnerable to cellular damage from reactive oxygen species (ROS), which are unstable molecules that can harm cellular structures