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daily from week 4), intestinal FITC-dextran 4 kDa permeability is reduced −34–42% versus vehicle at week 12 (measured by serum FITC fluorescence), claudin-5 and occludin intestinal expression are restored +1.4× and +1.3× respectively, and serum LPS (LAL assay) falls −28–34%

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S-glutathionylation S -glutathionylation is a redox-mediated PTM whereby glutathione (GSH) is conjugated to cysteine residues (P-SSG), leading to an increase of 305 Da and a net negative charge that can impact on protein structure and function