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Crucially, ApoER2 signaling in the brain is responsible for both early stage neuronal development and also adult synaptogenesis and learning in the “Reelin pathway” that is primarily activated through ApoE binding to ApoER2, for which ApoER2 is heavily expressed in the hippocampus and neocortex, in particular in granule cells and pyramidal cells (Fernández-Calle et al., 2022)

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Hence, the anti-neurogenic microbiome exerts its inhibitory effect by switching tryptophan catabolism from serotonin synthesis to the kynurenine production