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3.2.1 Adverse effects of biguanide Symptoms of the gastrointestinal tract (e.g., nausea, vomiting, diarrhea, and abdominal discomfort) are among the side effects linked with the therapeutic use of all biguanides (78, 91)

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However, in diseases such as T1DM, psoriasis, autoimmune hepatitis, and vasculitis, studies have also suggested that amino acid metabolic reprogramming may participate in the regulation of macrophage function and may exhibit directional effects and context-dependent differences that vary with tissue niche, stimulus spectrum, and disease stage (59, 80–82)