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Another model to assess the relative importance of endocrine versus paracrine/autocrine IGF-I is the liver-specific Ghr ko mouse

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Using the efficacy estimands, both doses of CagriSema met the primary endpoint to produce statistically significant and clinically relevant HbA 1c reductions compared with placebo: 18.4 mmol/mol with CagriSema 2.4 mg/2.4 mg