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It has been shown that the nephritogenic mouse monoclonal antibody R4A binds to a consensus pentapeptide sequence D/EWD/EYS/G (DWEYS), present in both NR2A and NR2B subunits of the mouse and human N-methyl-d-aspartate receptor (NMDAR)
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The slower absorption profile reduces peak plasma concentrations by 30-40%, potentially decreasing acute systemic reactions like nausea and fatigue while extending their duration
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