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In vivo studies confirmed that the USLP delivery system accumulates in the brain ( 3 O 4 TMZ-loaded obtained an excellent photothermal effect by synergistic combination of a chemo-phototherapy approach, increasing the anticancer effects in human glioblastoma cells by enhanced ROS generation ( 3 O 4 hybrid nano-system enhanced uptake and efficiency of TMZ treatment by a co-precipitation method (57)
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