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In the early 1970s, Alton Meister and his coworkers proposed that the two reactions shown in Figure 1 were part of a larger metabolic cycle that they named the γ -glutamyl cycle (45)

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Iron chelators such as DFO (100 μM) have been shown to downregulate TFR1 and reduce erastin-induced ferroptosis in SH-SY5Y dopaminergic neurons (Hadzhieva et al., 2013