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Thus, it appears important to evaluate vitamin B 12 status, as well as kidney function, in older individuals with elevated homocysteine levels prior to initiating homocysteine-lowering therapy

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Burrows (1979) found that toluidine blue given intravenously to sheep at a dose of 1.1 mg/kg reduced methaemoglobin produced by sodium nitrite, although the rate of reduction could be increased by the use of higher doses