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Acknowledgements This study was supported by the Natural Science Foundation of Beijing (7242129), the National Nature Science Foundation of China (82172211, 92268206, 82172231), the National Key Research and Development Programs of China (2022YFA1104300), the CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-5-059), the Military Medical Research Projects (2022-JCJQ-ZB-09600