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It has also been shown that NNMT directly upregulates connective tissue growth factor (CTGF) expression by reducing the methylation of the CTGF promoter, revealing a novel pathway linking metabolism and mesenchymal gene expression
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TB-500 provides critical enhancement of cellular migration and epithelial coverage that drives wound closure, with research demonstrating that topical or intraperitoneal TB-500 administration increases reepithelialization by 42% over controls at 4 days post-wounding and 61% at 7 days, with treated wounds showing enhanced contraction (at least 11% more than controls by day 7) and superior architectural organization
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