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A placebo-controlled trial in 252 patients with major depressive disorder who were randomized to 12-weeks’ NAC or placebo added to standard antidepressant treatment, and followed up to 16 weeks, found no significant differences in depressive symptoms assessed using the Montgomery-Ǻsberg Depression Rating Scale (MADRS) between the two groups at week 12 (primary endpoint) [144]
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70,71,72 As cell activity changes, its metabolism must be adjusted to accommodate any newly established biological energy/synthetic/catabolic requirements
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