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Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3

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So macrophages come in because they’re seeing this signal of LPS and think it’s a foreign invader, when it’s actually just a small dense LDL particle bound to LPS that came from the gut