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Taken together, the complex cellular components in TME of HCC dynamically interact through cell-cell contacts and cytokine signaling and exhibit considerable influences on tumor immune responses ( FIGURE 1 2.1.2 Non-cellular components in TME of HCC ECM containing extracellular substances, tumor vasculature system, exosomes, and cytokines are major non-cellular components in TME of HCC (Tahmasebi Birgani and Carloni, 2017)
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10.1016/j.clml.2014.01.007 47 WilkinsonH
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