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As the pathology progresses, the inner annulus fibrosus ruptures first, leading to localized protrusion of the nucleus pulposus (contained herniation)
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Increased oxidative stress causes modifications of all subcellular organelles, including oxidation of endoplasmic reticulum Ca 2+ -ATPase and contractile proteins (actin and myosin being the most important) resulting in contractile dysfunction (Steinberg 2013)
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