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In addition to P.g , F.n can activate the IL-17F/NF-κB pathway via NOD2–CARD3, upregulating IL-1β, IL-6, and TNF-α, thereby exacerbating ulcerative colitis (UC) and barrier disruption ( P.g infection and periodontitis, the above-mentioned systemic inflammatory factors are promoted to enter the central nervous system

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Consequently, many former smokers experience fewer sick days and an overall increase in their quality of life, as they are less frequently hindered by respiratory illnesses that once plagued them