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359 The inhibition of MELK expression significantly downregulates the expression of the ferroptosis-related genes PTGS2 and SLC39A14 and significantly reduces the expression of the lipid peroxidation marker 4-HNE and the oxidative stress marker MPO, thereby inhibiting macrophage infiltration and M1 polarization, reducing the secretion of proinflammatory factors, and alleviating intestinal tissue damage and intestinal inflammation

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A novel mechanism of G protein-coupled receptor functional selectivity