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First, mechanistic studies should integrate single-cell transcriptomics and spatial metabolomics to map cell-type-specific ferroptosis pathways in hippocampal and cortical neurons and microglia, with particular focus on the link between NCOA4-mediated ferritinophagy and Aβ clearance, thereby building a dynamic model connecting iron dysregulation, proteotoxic stress, and cell death
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If low B12 damages this sheath, nerve signals can misfire, leading to symptoms like tingling, numbness, or that awful ‘pins and needles’ feeling
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