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Additionally, topical application on burned and injured rats resulted in the downregulation of fibrotic genes ( TGF-β1 and α-SMA ) and the upregulation of angiogenic genes ( bFGF and VEGF )

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包含微粒BT化合物的口腔卫生组合物可另外包含一种或多种活性成分和/或一种或多种适用于口腔的赋形剂或载体。在一个实施方案中，所述口腔卫生组合物可另外包含碳酸氢钠或另外的碱性化合物或物质。由于碳酸氢钠的化学及物理性质，其具有广泛的应用，包括清洁、除臭和缓冲。碳酸氢钠化学上中和臭味，而非掩蔽或吸附它们。碳酸氢钠可与微粒BT化合物组合，或者作为粉末混合物或者溶解或悬浮于本文所述的牙粉、凝胶、糊剂和液体中的任一种。在其它实施方案中，微粒BT化合物可与有助于保持所需的碱性pH和还具有清洁和除臭性质的其它碱金属碳酸氢盐或碳酸盐物质(例如，碳酸氢钾或碳酸钙)组合。Oral hygiene compositions comprising particulate BT compounds may additionally comprise one or more active ingredients and/or one or more excipients or carriers suitable for the oral cavity