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“The use of magnetic resonance spectroscopy to observe changes in chemical composition of the brain over time is novel, and glutathione happens to be one of the few antioxidants you can detect with this approach,” Jeannie Padowski, the study’s senior investigator, said in a news release
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Based on lipidomics analysis, activated ACSL4 can catalyze the synthesis of lipid organisms containing polyunsaturated fatty acids (PUFA), leading to the accumulation of lipid peroxides, which in turn promotes ferroptosis [93]
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