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No adverse effects were noted in clinical trials (ulcerative colitis, phase II), and in toxicological studies, a lethal dose (LD1) could be not achieved (for review see [1,2,3,4,5,6,7,8,9,10,96,97,106,107,193])
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That property is exactly why it is preferred for vials that will be sampled more than once over several weeks in the lab
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