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Oxidative stress is thought to play a major role in neurodegeneration caused by traumatic brain injury and exposure to neurotoxins, and may be a factor in the course of many chronic neurodegenerative diseases, including Alzheimer disease (AD)
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While the specific mechanisms underlying these GSH/GSSG redox disturbances are not clear, these findings highlight the role of GSH/GSSG redox in asthma control and suggest that systemic measures of GSH and GSSG, as opposed to total glutathione alone, may be particular relevance in these subjects
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